Jeon-Hor Chen1,
2, Shadfar Bahri1, Rita S. Mehta3, Philip M.
Carpenter4, Christine E. Mclaren5, Wen-Pin Chen6,
David J. B. Hsiang7, Min-Ying Su1
1Center
for Functional Onco-Imaging,Department of Radiological Sciences, University
of California Irvine, Irvine, CA, United States; 2Department of
Radiology, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan; 3Department
of Medicine, University of California Irvine, Irvine, CA, United States; 4Department
of Pathology, University of California Irvine, Irvine, CA, United States; 5Department
of Epidemiology, University of California Irvine, Irvine, CA, United States; 6Chao
Family Comprehensive Cancer Center, University of California Irvine, Irvine,
CA, United States; 7Department of Surgery, University of
California Irvine, Irvine, CA, United States
This study was to investigate the role of multiple factors, including tumor characteristics, NAC regimens, MR systems, and time to operation, in affecting the accuracy of MRI evaluation of residual tumor size following NAC treatment. A total of 98 patients were studied. Univariate analysis revealed significant predictors including tumor type, morphology, ER, and MR scanner. Multivariate regression analyses demonstrated that only tumor type, tumor morphology, ER status, and HER-2 were independent predictors (all p<0.05). MRI diagnosis is less accurate in cancers with lobular component, cancers presenting non-mass-like enhancements, and cancers with ER positive and HER-2 negative status.