Abstract #0151

in-vivo 29Si Magnetic Resonance Imaging of Hyperpolarized Silicon Particles

Maja Cassidy¹, Henry Chan², Pratip Bhattacharya²,³, Charles Marcus¹,⁴

¹Harvard University, Cambridge, MA, United States; ²Huntington Medical Research Institutes, Pasadena, CA, United States; ³Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, United States; ⁴University of Copenhagen, Copenhagen, Denmark

We report direct in-vivo imaging of hyperpolarized silicon microparticles by ²⁹Si MRI. Hyperpolarization of the ²⁹Si nuclei is generated by dynamic nuclear polarization using electronic defects that naturally occur at the particle surface, and so no additional radical is required. Applications to gastrointestinal, intravascular, and tumor perfusion imaging at sub-picomolar concentrations are presented.