1Laboratory
for Functional and Metabolic Imaging, Center for Biomedical Imaging, Ecole
Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 2Dpartement
de l'Enfant et de l'Adolescent, Unit de Gastroentrologie, Hpitaux
Universitaires de Genve, Geneva, Switzerland; 3University of
Geneva , Geneva, Switzerland; 4University of Lausanne , Lausanne,
Switzerland; 5Service de Pathologie Clinique, Hpitaux
Universitaires de Genve, Geneva, Switzerland; 6Transplantation
Division, Department of Surgery, University of Geneva Hospitals, Geneva,
Switzerland; 7University of Pavia, Pavia, Italy; 8Unit
de radiologie abdominale, Service de Radiologie, Hpitaux Universitaires de
Genve, Geneva, Switzerland; 9Laboratory for Functional and
Metabolic Imaging, Center for Biomedical Imaging, cole Polytechnique
Fdrale de Lausanne, Lausanne, Switzerland; 10University of
Lausanne, University of Geneva, Lausanne, Geneva, Switzerland
Portosystemic shunting may be the most significant problem associated with C57BL/6 inbreeding both for its effect on gene expression in the central nervous system and its systemic repercussions.