Multi-Bolus Pulsed ASL for Improved Renal Perfusion Quantification

Xiang He¹, Serter Gumus¹, Ayaz Aghayev¹, Kyongtae Ty Bae¹

High pulsatile blood flow/velocity in the descending aorta renders the labeling bolus of a standard pulse ASL (PASL) experiment to be limited within a single cardiac RR interval. In this study, we took advantage of such temporally uneven blood flow to generate multiple labeling boluses across consecutive RR intervals. We demonstrated that the proposed multi-bolus PASL scheme improved the sensitivity of renal PASL perfusion signal by ~30 to 50%.