Sophie F. Riches1,
Geoffrey S. Payne1, Nandita M. deSouza1, Scott Morgan2,
David Dearnaley3, Veronica A. Morgan1, Sharon L. Giles1,
Mike Partridge4
1CR-UK
and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal
Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; 2Division
of Radiation Oncology, University of Ottawa, Ottawa, Ontario, Canada; 3Division
of Radiotherapy & Imaging, Institute of Cancer Research and Royal Marsden
NHS Foundation Trust, Sutton, Surrey, United Kingdom; 4Gray
Institute for Radiation Oncology and Biology,Department of Oncology,
University of Oxford, Oxford, Oxfordshire, United Kingdom
The use of a boosted radiation dose to a tumour nodule within the prostate is limited by poor accuracy for tumour localisation on morphological imaging; functional imaging offers more accurate delineation of the dominant intraprostatic lesion. This study uses a model that combines multifunctional MR parameters to define an intraprostatic lesion and plans an 84 Gy radiation boost to functional imaging-defined tumour with IMRT. Compared to a standard clinical treatment of 72 Gy applied uniformly across the prostate, a focal boost resulted in a greater therapeutic ratio, with potentially greater tumour control and fewer side-effects from the treatment.