Abstract #0065

Evaluation and Validation of Pulse Wave Velocity Measurements from 2D and 4D PC MRI in Swine with Familial Hypercholesterolemia: Initial Results

Andrew L. Wentland¹,², Thomas M. Grist,²³, Dhanansayan Shanmuganayagam⁴, Christian G. Krueger⁴, Patrick E. McBride⁵, Jennifer J. Meudt⁴, Jess D. Reed⁴, Oliver Wieben¹,²

¹Medical Physics, University of Wisconsin School of Medicine & Public Health, Madison, WI, United States; ²Radiology, University of Wisconsin School of Medicine & Public Health, Madison, WI, United States; ³Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; ⁴Animal Sciences, University of Wisconsin, Madison, WI, United States; ⁵Medicine, University of Wisconsin School of Medicine & Public Health, Madison, WI, United States

The purpose of this study was to evaluate pulse wave velocity (PWV) measurements derived from 2D and 4D phase contrast MRI in swine with hypercholesterolemia and to compare these measurements to those derived from gold standard pressure probes. Bland-Altman analysis revealed relatively small differences between the MR and pressure probe PWV values; there was less variability with the 4D PWV measurements than with the 2D techniques. Correlation to pressure probe measurements was stronger with the 4D technique than with the 2D techniques. The 4D acquisition provides a promising means of computing PWV in a swine model of atherosclerosis.