Abstract #0029

Combination of Non-Invasive Parametric MRI and Invasive Physiological Measurements: Towards a Hybrid and Integrated Approach for Investigation of Acute Kidney Injury

Jan Hentschel¹, Kathleen Cantow², Andreas Pohlmann¹, Karen Arakelyan,¹², Bert Flemming², Mechthild Ladwig², Erdmann Seeliger², Uwe Hoff³, Pontus B. Persson², Thoralf Niendorf¹,⁴

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine, Berlin, Germany; ²Institut fr Vegetative Physiologie, Charit Campus Mitte, Berlin, Germany; ³Nephrology and Intensive Care Medicine, , Charit Universittsmedizin Berlin, Campus Virchow- Klinikum, Berlin, Germany; ⁴Experimental and Clinical Research Center a joint cooperation between the Charit Medical Faculty, and the Max-Delbrueck Center for Molecular Medicine, Berlin, Germany

Renal medullary hypoperfusion and hypoxia play a pivotal role in acute kidney injury. Invasive but quantitative physiological methods are used for targeted probing of kidney perfusion as well as regional perfusion and oxygenation in animals in vivo. We set out to combine invasive techniques and non-invasive MRI in an integrated hybrid setup with the ultimate goal to monitor and interpret parametric MR and physiological parameters by means of standardized interventions. Our preliminary results demonstrate that simultaneous measurement of tissue pO₂, flux, renal blood flow, arterial blood pressure and MRI is feasible.