Accelerated Multi Echo Based Echo-Planar J-Resolved Spectroscopic Imaging: Implementation and Quantitation of Cerebral Metabolites

Manoj Kumar Sarma¹, Rajakumar Nagarajan¹, Neil Wilson¹, Jon Furuyama¹, M. Albert Thomas¹

Four dimensional (4D) multi-echo (ME) echo planar (EP) based J resolved spectroscopic imaging (ME-EP-JRESI) technique is more robust and enables simultaneous recording of two dimensional (2D) JPRESS spectra in multiple regions with better spectral and spatial resolution than the conventional magnetic resonance spectroscopic imaging (MRSI) approaches recording one dimensional (1D) MRS. These results demonstrate that ProFit processing of 2D JPRESS spectra extracted from the ME-EP-JRESI data provides additional metabolites with reduced CramrRao lower bound (CRLB) values (< 20%) in rhe healthy human brain.