Uzay Emrah Emir1, Noam Harel1, Essa Yacoub1, Gregor Adriany1, Gulin Oz1
1University of Minnesota, Minneapolis, MN, United States
Non-human primate models of neurological diseases serve as a critical link between basic research and human clinical applications. Therefore, reliably measuring neurochemical levels, which may serve as disease biomarkers and enhance understanding of mechanisms of neurological diseases, in the monkey brain is of great interest. Here we demonstrate the feasibility of acquiring and quantifying single voxel semi-LASER spectra by utilizing a custom build monkey coil at 7T. Representative spectra and neurochemical profiles are reported from brain regions that are of interest for various neurological disorders, namely the posterior cingulate, putamen and cerebellum. Neurochemical similarities between humans and monkeys were observed