Hedok Lee1, Elisabeth Caparelli2, Haifang Li3, Ruth Reinsel1, Amit Mandal1, David Smith4, Shaonan Zhang1, Helene Benveniste1
1Anesthesiology, State University of New York at Stony Brook, Stony Brook, NY, United States; 2Neuroscience Center, State University of New York at Stony Brook, Stony Brook, NY, United States; 3Radiology, State University of New York at Stony Brook, Stony Brook, NY, United States; 4Medical, Brookhaven National Laboratory, Upton, NY, United States
In proton magnetic resonance spectroscopy (1HMRS), partial volume effect is inevitable and substantial uncertainty is introduced in metabolite concentration calculations when water is used as an internal reference. The present study focuses on methodological aspects pertaining to mapping the 1HMRS voxel onto the corresponding anatomical scan and results are compared on the basis of positional accuracy, positional reliability, and metabolite concentration estimates. We found computerized or manual voxel placement methods are equally valid. We also found significant correlation between metabolite concentrations and GM tissue volume fractions confirming previous studies.