Koji
Sagiyama1, Osamu Togao1, Tomoyuki Mashimo2,
3, Kim Kangasniemi1, Vamsidhara Vemireddy, 34,
Kimmo J. Hatanpaa5, Melissa A. Maddie, 34, Robert M.
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States; 2Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States; 3Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, United States; 4Department of Neurology, UT Southwestern Medical Center, Dallas, TX, United States; 5Departement of Pathology, UT Southwestern Medical Center, Dallas, TX, United States
Amide proton transfer (APT) imaging shows increasing interest in characterization of the brain tumor. The objective of our study is to investigate whether APT imaging can be used for monitoring treatment responses of the brain tumor in chemotherapy. In the present study, we compared the temporal changes of APT ratio in glioblastoma multiforme (GBM) in a mouse model with and without chemotherapy by Temozolomide which is widely used for the treatment of GBMs.