Brett
William Clive Kennedy1, 2, Mikko Iivari Kettunen1,
2, De-En Hu1, 2, Sarah Elizabeth Bohndiek1,
2, Kevin Michael Brindle1, 2
1Department of Biochemistry, University of Cambridge, Cambridge, England, United Kingdom; 2Cambridge Research Institute, Cancer Research UK, Cambridge, England, United Kingdom
The aim of this study was to use hyperpolarized 13C labeled ketone bodies to examine metabolism in vivo. Despite high polarization (~25%) and long T1 values (~35s), little in vivo metabolism was observed in our current models. Nevertheless, we hope these molecules may still have important roles to play in our understanding of mitochondrial redox state in vivo.