Jae Mo Park1, 2, Lawrence Recht3, Sonal Josan2, 4, Taichang Jang3, Milton Merchant3, Yi-Fen Yen5, Ralph E. Hurd5, Daniel M. Spielman, 12,
1Electrical Engineering, Stanford University, Stanford, CA - California, United States; 2Radiology, Stanford University, Stanford, CA - California, United States; 3Neurology and Neurological Sciences, Stanford University, Stanford, CA - California, United States; 4Neuroscience Program, SRI International, Menlo Park, CA - California, United States; 5Applied Science Laboratory, GE Healthcare, Menlo Park, CA - California, United States
We demonstrate that measuring 13C-Bic is feasible to assess PDH flux and effect of DCA in tumor-bearing rat brain by injecting hyperpolarized [1-13C]Pyr. Lac/Bic gave a better contrast between glioma and normal brain, and reflected both pathways to cytoplasmic and mitochondrial metabolism.