Jae Mo Park1, 2, Ralph E. Hurd3, Sonal Josan2, 4, Yi-Fen Yen3, Adolf Pfefferbaum4, 5, Dirk Mayer, 24, Daniel M. Spielman, 12
1Electrical Engineering, Stanford University, Stanford, CA - California, United States; 2Radiology, Stanford University, Stanford, CA - California, United States; 3Applied Science Laboratory, GE Healthcare, Menlo Park, CA - California, United States; 4Neuroscience Program, SRI International, Menlo Park, CA - California, United States; 5Psychiatry, Stanford University, Stanford, CA - California, United States
Bi-directional metabolic conversion can be estimated by simultaneously injecting both co-polarized substrates. The amount of flux and isotopic exchange can be estimated by the difference in flow of each substrate. We demonstrate the differentiation of flux and isotopic exchange between Pyr and Lac by injecting polarized [2-13C]Pyr and [1-13C]Lac together, and observed increased flux from Pyr to Lac after EtOH infusion.