Abstract #4077

Evaluation of Imatinib Mesylate as a Possible Treatment for Nephrogenic Systemic Fibrosis in a Rat Model

Thomas A. Hope¹, Philip LeBoit², Whitney A. High³, Yanjun Fu⁴, Robert C. Brasch⁴

¹Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States; ²Dermatology, UCSF, San Francisco, CA; ³Dermatology, University of Colorado, Denver, CO; ⁴Radiology, UCSF, San Francisco, CA

We have evaluated the efficacy of imatinib mesylate for the treatment of nephrogenic systemic fibrosis in a high dose GBCA animal model and have demonstrated that the administration of imatinib results in decreased lesion severity suggesting that imatinib may be effective in the treatment of NSF in humans.