Fabian Zimmer1, Frank G. Zoellner1, Simone Hoeger2, Sarah Klotz2, Charalambos Tsagogiorgas3, Lothar R. Schad1
1Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany; 2Department of Medicine V, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany; 3Clinic for Anaesthesiology and Intensive Care, Heidelberg University, Mannheim, Germany
The assessment of kidney function by measuring renal microvascular perfusion is crucial to diagnose and treat renal diseases at an early stage of progression. MRI provides two techniques to assess renal perfusion: Dynamic contrast-enhanced (DCE)-MRI and arterial spin labelling (ASL). In this study, ASL has been established to quantitatively measure renal cortical perfusion in rats with unilateral ischaemic acute renal failure. The ASL estimates were compared against those obtained by DCE-MRI. Both methods are in good agreement and show no statistical differences. Furthermore, both methods depict significant blood flow differences between healthy and diseased kidneys.