Liver Fat Quantification with MRI: Comparison of 2 Point-Dixon and 3 Point-Dixon Methods to T2 Corrected Multiecho Single-Voxel Spectroscopy

Janakan Satkunasingham¹, Ami Shah², Stephan Kannengiesser³, Andre De Oliveira³, Marcello Facciuto², Bachir Taouli²

In this study involving a large number of patients (n=211), we have compared the diagnostic accuracy of 2 point Dixon and 3 point Dixon sequences to T2-corrected multiecho MR spectroscopy used as the reference standard. Hepatic iron deposition was determined using a breath-hold multi-echo T2* sequence. Results demonstrated the superiority of the 3 point Dixon over the 2 point Dixon method for quantifying hepatic fat, mainly related to the presence of concomitant iron deposition.