Hooman Hamedani1, Masaru Ishii2, Kiarash Emami1, Stephen J. Kadlecek1, Yi Xin1, Puttisarn Mongkolwisetwara1, Nicholas N. Kuzma1, Biao Han1, Harrison McAdams3
1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States; 3Biological Basis of Behavior Program, University of Pennsylvania, Philadelphia, PA, United States; 4Radiology, University of Virginia, Charlottesville, VA, United States; 5Medicine, University of Pennsylvania, Philadelphia, PA, United States
Four healthy non-smokers and four asymptomatic smokers underwent three repetitions of hyperpolarized 3He MRI imaging in a two-week period to obtain a measure of intraclass test-retest repeatability for an oxygen-weighted 3He MRI scheme to measure the regional alveolar partial pressure of oxygen. 12 slices were imaged during a 12-second breath-hold with a reasonable spatial resolution. Inter and intraclass repeatability was measured for both global and regional distributions of partial pressure of oxygen in subjects. A mixed-effect model with random effects was regressed to 3x3x3 cm3 voxels of all human subjects to estimate a correlation coefficient for each group.