Kai Jiang1, 2, Ya Chen1, 2, Raymond F. Muzic, Jr., 13, Xin Yu1, 2
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 2Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States; 3Department of Radiology, Case Western Reserve University, Cleveland, OH, United States
A mathematical model was developed for quantitative assessment of the L-type calcium channel activity with manganese-enhanced MRI. Dynamic changes in R1 during manganese perfusion and wash-out were followed with rapid T1 mapping at 3 min temporal resolution. Manganese uptake via the L-type calcium channel and efflux via the NCX were estimated by least-squares fitting of the model to experimental MEMRI data.