Michael Salerno1, 2, Rajesh Janardhanan3, Nebiyu Adenaw3, Ronny S. Jiji3, Frederick H. Epstein, 24, Christopher M. Kramer2, 5
1Internal Medicine, Cardiology, University of Virginia, Charlottesville, Va, United States; 2Radiology, University of Virginia, Charlottesville, VA, United States; 3Internal Medicine, Cardiology, University of Virginia, Charlottesville, VA, United States; 4Biomedical Engineering, University of Virginia, Charlottesville, VA, United States; 5Internal Medicine, Cardiology, University of Virgina, Charlottesville, VA, United States
Diffuse myocardial fibrosis can occur in hypertensive left ventricular hypertrophy (LVH) and is not detectable by conventional late gadolinium enhanced imaging. We utilized T1 mapping techniques to quantify myocardial fibrosis by determining the partition coefficient and volume of distribution of Gd-DTPA. We demonstrate a significant increase in these parameters in hypertensive patients with LVH as compared to age matched normal controls.