Is Ribose and Creatine Supplementation Beneficial in Chronic Heart Failure? an in vivo 1H-MRS / 31P-MRS / Cine-MRI Study in Murine Hearts

Kiterie M.E. Faller¹, Craig A. Lygate¹, Mahon L. Maguire¹, Debra J. Medway¹, Victoria L. Thornton¹, Stefan Neubauer¹, Jurgen E. Schneider¹

The failing heart is characterised by a decrease in myocardial creatine, adenine nucleotides, and high-energy phosphate metabolites. In a mouse model of permanent coronary artery ligation, we tested the hypothesis whether simultaneous elevation of myocardial creatine and ribose would be beneficial by increasing cardiac energy availability. Using a combination of ¹H-MRS, ³¹P-MRS, cine-MRI to measure total creatine, phosphocreatine (PCr)/ATP ratio, cardiac function/mass and infarct size, we did not observe any beneficial or deleterious effect of this therapeutic approach in post-infarct left ventricular remodelling or function.