Martha J. Holmes1, 2, Zhaohua Ding1, 2, Xue Yang3, Bennett A. Landman, 23, John C. Gore1, 2, Bassel Abou-Khalil4, Hasan H. Sonmezturk4, Vi
1Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States; 2Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 3Electrical Engineering, Vanderbilt University, Nashville, TN, United States; 4Neurology, Vanderbilt University, Nashville, TN, United States
Temporal lobe epilepsy (TLE) is associated with gray matter loss and changes in functional connectivity. The objective of our analysis is to examine the voxel-wise relationship between gray matter concentration (GMC) and resting state functional connectivity to the thalamus in TLE. We found the following: a cluster in the left precuneus/posterior cingulate demonstrated increased negative connectivity to the left thalamus as GMC decreased, and a cluster in the left putamen/insula displayed increased connectivity as GMC decreased in the thalamus. The changes in GMC and functional connectivity in these structures provides further evidence of their involvement in the TLE seizure network.