Abstract #3632

MRI Biomarkers Capable of Detecting Effects of an Experimental Pharmacologic Therapy for Idiopathic Normal Pressure Hydrocephalus

Milos Ivkovic¹, Heather Katzen², Ilhami Kovanlikaya³, Ahmet Bagci², Linda Heier³, Noam Alperin², Ashish Raj³, Norman Relkin³

¹Weill Cornell Medical College, New York City , NY , United States; ²University of Miami School of Medicine, Miami, FL; ³Weill Cornell Medical College, New York City, NY, United States

There are no proven pharmacologic treatments for Normal Pressure Hydrocephalus (NPH). Acetazolamide (ACZ) is known to reduce CSF production and interstitial edema. We hypothesized that a low dose of ACZ would reduce CSF production and brain interstitial fluid in NPH.