Emil Harald Jeroen Nijhuis1, 2, Douwe P. Bergsma3, 4, Albert V. van den Berg5, 6, Anne-Marie van Cappellen van Walsum2, 7, David G. Norris1, 8
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Gelderland, Netherlands; 2MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, Overijssel, Netherlands; 3Department of Functional Neurobiology, Utrecht University, Helmholtz Research School, Netherlands; 4Department of Cognitive Neuroscience, University Medical Centre St Radboud, Netherlands; 5Department of Cognitive Neuroscience, Utrecht University, Helmholtz Research School, Netherlands; 6Department of Cognitive Neuroscience, University Medical Centre St Radboud, Nijmegen, Netherlands; 7Department of Anatomy, University Medical Centre St Radboud, Nijmegen, Netherlands; 8Erwin L Hahn Institute for MRI, Universitt Duisburg-Essen, Germany
To determine the impact of a cerebral lesion on the neocortical network it is necessary to know its state in unharmed condition. We circumvent this problem by homotopically mapping a lesion to a healthy sample population and simulating its impact using a reachability and distance based measure.