Dominique L. Jennings1, Daniel B. Chonde2, Jayashree Kalpathy-Cramer3, Kim Mouridsen4, Gregory Sorensen3, Alexander Guimaraes5, Bruce Rosen3, Tracy Batchelor6, Elizabe
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital , Boston, MA, United States; 2HST, Massachusetts Institute of Technology, Boston, MA, United States; 3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States; 4Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 5Department of Radiology, Massachusetts General Hospital, Boston, MA, United States; 6Department of Neurology and Cancer Center, Massachusetts General Hospital, Boston, MA, United States
Phase-based DCE-MRI measurements of the vascular input function are insensitive to common imaging-related artifacts observed in magnitude-based vascular input functions. Here we propose the use of PET-based vascular input functions to evaluate the differences between the two MR-based measurements and relative effects of both on estimates of Ktrans.