Principal Components Analysis of Whole Trial Onset Aligned DCE-MRI Gadolinium Uptake Curves Produces Metrics That Correlate with Conventional PK Parameter Estimates

Matt N. Gwilliam¹, David J. Collins¹, Martin O. Leach¹, Matthew R. Orton¹

Analysing DCE-MRI Gadolinium uptake curves from a cohort of patients using principal component analysis can produce metrics that correlate with pharmacokinetic parameters and retain their meaning across datasets implying that treatment effects can be detected. This work demonstrates that these correlations can be improved further by taking into account onset time.