Youngkyoo Jung1, 2, Megan Johnston2
1Radiology, Wake Forest School of Medicine, Winston-Salem,, NC, United States; 2Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC, United States
3D ASL imaging provides high SNR benefit over 2D methods. Segmented 3D acquisition methods covering the entire k-space during multiple labeling periods are often preferred to reduce blurring in the slice encoding direction. However, applications of the segmented acquisition are limited to baseline perfusion imaging. We propose an interleaved 3D spiral FLASH imaging method that collects the entire k-space within a single labeling period which offers high temporal resolution, and reduces geometric distortions. We also investigated the trade-off between the number of interleaves and SNR benefit. The proposed method would be beneficial to various ASL applications.