Mengchao Pei1, 2, Thanh D. Nguyen1, Lijia Wang2, Tian Liu1, Mitch Anthony Cooper1, Jianqi Li2, Yi Wang1, 2
1Weill Cornell Medical College, New York, NY, United States; 2Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China
A novel T2* mapping method based on the definite integral of the T2* signal decay curve (DISC) is proposed. Numerical simulations show that this method is more robust against noise effect than the widely used Levenberg-Marquardt (LM) algorithm, particularly at low SNR. DISC can reduce T2* data fitting time for a brain data set from 20 hours by LM to 5 minutes. This method is easy to implement and does not require an initial guess.