Benjamin Schmitt1, Siegfried Trattnig, Claudia Sallinger, Jochen Hofsttter, Reinhard Windhager, Stephan Domayer
1Centre for High-Field MR, Medical University of Vienna, Vienna, Austria
The study was performed to assess to which extent gagCEST signal intensities measured with a clinical 3 T MR scanner in ankle cartilage correlate to cartilage GAG content as determined by the gold standard, biochemical quantification of GAG. Therefore, 7 ankles from human cadavers were examined with both techniques in an in-vitro study and linear correlations were found between them, which suggests that gagCEST imaging reflects GAG content in cartilage tissue.