Nuria Maria Hirsch1, Christine Preibisch1, 2, Vivien Tth1, Jrgen den Hollander1, Annette Frschler1, Hendrik Kooijman3, Claus Zimmer1
1Department of Neuroradiology, Klinikum rechts der Isar der TU Mnchen, Mnchen, Germany; 2Department of Neurology, Klinikum rechts der Isar der TU Mnchen, Mnchen, Germany; 3Clinical Application, Philips Healthcare, Hamburg, Germany
Hypoxia is assumed to promote the development and proliferation of tumor stem cells especially in highly malignant and aggressive tumors The BOLD effect provides a method for oxygenation dependent contrast, but for an absolute quantification of oxygen saturation T2, T2* and CBV have to be measured additionally. In this study, hypoxia was mapped semi-quantitatively from those parameters with an emphasis on fast imaging methods that can easily be employed in the clinic.