Rossella Canese1, Paola Porcari1, Luisa Altabella1, Francesca Zoratto1, Francesco de Pasquale2, Giovanni Laviola1, Walter Adriani1
1Cell Biology and Neurosciences, Istituto Superiore di Sanita', Rome, Italy; 2Institute for Advanced Biomedical Technologies, G. DAnnunzio University, Chieti, Italy
LP211 is an agonist of serotonin (5-hydroxytryptamine, 5-HT) receptor 7 (5-HT7). It is proposed for a role in neurogenesis and in patho-physiological processes like anxiety / depression, cognitive / sleep disturbances, and impaired coping with stress. Here, we investigated the long-term consequences of developmental exposure to LP211 on brain metabolism (by in vivo 1H MRS), anatomy (by DTI) and functionality (by functional connectivity). We detect enduring metabolic, anatomic and functional modifications which may perhaps indicate rearrangement in forebrain networks.