Minjie Wu1, Lisa H. Lu1, 2, Alessandra M. Passarotti1, Ezra Wegbreit1, Jacklynn Fitzgerald1, Mani N. Pavuluri1
1Psychiatry, University of Illinois at Chicago, Chicago, IL, United States; 2Psychiatry, Roosevelt University, Chicago, IL, United States
An understanding of the neural operations impacted by pediatric bipolar disorder (PBD) is essential for the discovery of optimal treatment targets for this serious illness. The present study evaluates the resting state functional connectivity underlying structural and functional abnormalities reported in PBD using model-free independent component analysis approach. Three distinct resting state networks, comprising regions involved in affective, executive, or sensorimotor functions, exhibited significant differences in regional connectivity between PBD and healthy control (HC) groups.