Tom Struys1, 2, Tom Dresselaers1, Sarah Caers1, Wouter Oosterlinck3, Ann Van Santvoort1, Ivo Lambrichts2, Uwe Himmelreich1
1Department of Medical Diagnostic Sciences, Katholieke Universiteit Leuven, Leuven, Belgium; 2Department of Functional Morphology, Universiteit Hasselt, Diepenbeek, Belgium; 3Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
This study reports on the longitudinal changes in CBF and CVR, assessed by ASL, in free breathing and ventilated animals which underwent a permanent unilateral ligation of the common carotid artery (CCA). Data indicate that a specific vascular response is elicited upon CCA ligation which suggests a temporal limitation in auto regulation of the vascular network and a spontaneous recovery over time. These findings provide a better understanding of the effect of a permanent CCA ligation and how it contributes to the interpretation of the dynamics observed in the penumbra CBF in the mouse transient MCAO model for stroke.