Thomas D. OSullivan1, Anais Leproux1, Jeon-Hor Chen2, Orhan Nalcioglu2, Bruce J. Tromberg1, Min-Ying Lydia Su2
1Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA, United States; 2Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, CA, United States
The breast density from the contralateral normal breast of patients receiving neoadjuvant chemotherapy was measured using two imaging modalities, MRI and broadband Diffuse Optical Spectroscopic Imaging (DOSI). The fibroglandular tissue volume measured on MRI was compared to the concentration of water, lipid, oxyhemoglobin, deoxyhemoglobin, and oxygen saturation measured by DOSI. The strongest MRI-DOSI correlation was found with water and deoxyhemoglobin concentration. Chemotherapy is known to decrease density due to suppressed ovarian function. The change of density may provide a prognostic marker of this process. Compared to MRI, DOSI may provide a less expensive bed side imaging device for this purpose.