He Zhu1, 2, Kelly Myers1, Michael Schar, 13, Peter B. Barker1, 2
1Radiology, Johns Hopkins University, Baltimore, MD, United States; 2FM Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States; 3Philips Healthcare, Cleveland, OH, United States
A 3D PRESS MRSI sequence was developed for tCho detection in the breast. This novel sequence consisted of a dualband pre-saturation and dualband dephasing before echo formation (BASING). Both methods, either method and unsuppressed scans were tested in 2D MRSI to evaluate their performances by normalizing residual signals to unsuppressed signals (water and lipid). The combination achieved reduction factors of less than 1% for both water and fat. As 3D MRSI was implemented with the combination, tCho signal was detected in healthy breast tissues.