Xin Li1, Ryan A. Priest2, 3, William J. Woodward1, Faisal Siddiqui2, 3, Tomasz M. Beer4, 5, Mark G. Garzotto6, 7, William D. Rooney1, Char
1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 2School of Medicine, Oregon Health & Science University, Portland, OR, United States; 3Radiology, Oregon Health & Science University, Portland, OR, United States; 4Hematology/Oncology, Oregon Health & Science University, Portland, OR, United States; 5Knight Cancer Institute, Oregon Health & Science University, Portland, OR, United States; 6Urology, Oregon Health & Science University, Portland, OR, United States; 7Portland VA Medical Center, Portland, OR, United States
For prostate Dynamic-Contrast-Enhanced MRI (DCE-MRI), water exchange effects become more influential with high interstitial contrast reagent concentration. Using real data and simulations based on region-of-interest prostate DCE-MRI, pharmacokinetic parameters extracted from the fast-exchange-limit-constrained (FXL-c) Standard pharmacokinetic modeling (SM) and versions of shutter-speed models (SSM) were investigated. The first generation SSM (SSM1) was found sensitive to inter-compartmental water exchange effects. With inclusion of the mean intracellular water lifetime biomarker, the effect on Ktrans (a CR extravasation rate measure) can be quantified using the difference of its magnitudes returned by sequential SSM1 and SM analyses of a given DCE-MRI time-course.