Karen Y. Oh1, Luminita A. Tudorica1, Nicole Roy1, Mark D. Kettler1, Xin Li1, Yiyi Chen1, Aneela Afzal1, John W. Grinstead2, Gerhard Laub3, Wei Huang1
1Oregon Health & Science University, Portland, OR, United States; 2Siemens Healthcare, Portland, OR, United States; 3Siemens Healthcare, San Francisco, CA, United States
Thirty one patients with 36 suspicious breast lesions underwent DCE-MRI prior to biopsies using a commercially available GRE-based TWIST sequence, a k-space undersampling and data sharing acquisition strategy. 18 or 20 s temporal resolution was obtained along with 1x1x1.4 mm3 spatial resolution. Single-frame DCE images were acquired immediately following TWIST DCE-MRI using a conventional full-k-space-sampling GRE sequence. Excellent intra- and inter-radiologist reader agreement in tumor morphology evaluation was achieved when comparing the last TWIST DCE image set with the conventional GRE images. Shutter-Speed model pharmacokinetic analyses of TWIST DCE-MRI data improved diagnostic accuracy compared to that obtained with ACR BIRADS Lexicon.