Durgesh Kumar Dwivedi1, Rajeev Kumar2, Sanjay Thulkar3, Sanjay Sharma3, Amit K. Dinda4, Naranamangalam R. Jagannathan1
1Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; 2Department of Urology, All India Institute of Medical Sciences, New Delhi, Delhi, India; 3Department of Radio-diagnosis, All India Institute of Medical Sciences, New Delhi, Delhi, India; 4Department of Pathology, All India Institute of Medical Sciences, New Delhi, Delhi, India
Gleason grading is predictor of aggressiveness and disease outcome in prostate cancer (PCa) patients and its reproducibility might depend upon clinical factors and pathologist experience. For accurate treatment selection for PCa it is essential to know the Gleason score (GS) accurately on TRUS biopsy or final GS on radical prostatectomy specimens. In order to improve pretreatment prediction of PCa aggressiveness, we performed a prospective study to evaluate PCa aggressiveness based upon apparent diffusion coefficient (ADC) values derived from diffusion weighted MRI. Our study indicated that ADC values could be used as a noninvasive method in the prediction of PCa aggressiveness.