Hulong Lei1, Chao Zou1, Di Pan1, Norman Beauchamp2, Xiaoming Yang2, Tom Matula3, Bensheng Qiu1, 2
1Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Chinese Academy of Sciences, Shenzhen, Guangdong, China; 2Department of Radiology, University of Washington School of Medicine, Seattle, United States; 3Applied Physics Laboratory, Center for Industrial and Medical Ultrasound, University of Washington, Seattle, United States
In this study, an closed cell labeling system was designed to reduce contamination and be efficient for clinical applications, using focused ultrasound, and one experiment was conducted to validated the feasibility of the magnetosonoporation (MSP) cell labeling apparatus. The results indicated that MSP is an instant, safe and efficient magnetic cell labeling technique for non-invasive MRI stem cell tracking in vivo and the design of MSP apparatus was beneficial to reduce cell contamination potential and convenient for future clinical applications.