Adam J. Pattison1, Matthew DJ McGarry1, John B. Weaver1, 2, Keith D. Paulsen1, 3
1Thayer School of Engineering, Dartmouth College, Hanover, NH, United States; 2Radiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States; 3Norris Cotton Cancer Center, Lebanon, NH, United States
Intrinsically-activated MR elastography has been shown to give reasonable results for brain tissue and detect differences between normal and hydrocephalic patients. However, natural changes in metabolism and blood pressure over time can change the mechanical property signature of a healthy subject. The aim here is to see if intrinsic activation is sensitive to changes in a healthy subject over time and, also, sensitive to changes amongst a healthy population. Results indicate that this technique detects a slightly larger mechanical property variation over time and has a much smaller variation for a single subject than among a group of healthy subjects.