Abstract #2341

Investigation of CEST Effects in Hexoses and Pentoses of the Glycolytic Pathway

Francisco Torrealdea¹, Marilena Rega¹, Mark Lythgoe², David Thomas¹, Simon Walker Samuel², Xavier Golay¹

¹UCL Institute of Neurology, University College London, London, United Kingdom; ²UCL Center of Advanced Biomedical Imaging, University College London, United Kingdom

Detection of CEST signal in vivo from the hexoses and pentoses of the Glycolytic pathway would allow distinguishing the GlucoCEST signal is coming from extracellular or intracellular origin. This would open the possibility of exploring the kinetics of the cancer metabolism non-invasively under the MRI. In this preliminary study we show that both hexoses (glucose and glucose-6-phosphate) give an enhanced CEST signal compared to the pentoses (fructose-6-phosphate and fructose-1,6-biphosphate). Despite this could be a limitation of the extend of this technique, the high CEST signal from fructose-1,6-biphosphate suggests the feasibility of detecting intracellular metabolic activity.