Pseudocontinuous ASL (PCASL) Combined with EPI, RARE and TrueFISP for High Resolution Multi-Orientation Mouse Brain Perfusion Imaging

Guillaume Duhamel¹, Virginie Callot¹, Patrick J. Cozzone¹

Mouse models of human brain diseases are extensively studied with long scan time multimodal MR protocols that include functional, metabolic and structural approaches. To further describe the pathologies, there is a real need for a high resolution, sensitive method which allows assessing quantitative whole brain perfusion within a reasonable scan time. This work presents the use of the ubpCASL technique in combination with fast imaging sequences for the acquisition of high resolution quantitative CBF maps within a short scan time protocol. The pCASL inversion efficiency was measured and multi-orientation acquisitions were investigated