Abstract #1967

Temporal Requirements in Dynamic Contrast-Enhanced MRI of Glioblastoma Multiforme

Magne Mrk Kleppest¹, Christopher Larsson¹, Raimo Aleksi Salo¹, Jonas Vardal¹, Kine Mari Bakke², Knut Lote³, Petter Brandal³, I. Andre Rasmussen¹, Atle Bjrnerud¹,²

¹The Intervention Centre, Oslo University Hospital, Rikshospitalet, Oslo, Norway; ²Department of Physics, University of Oslo, Oslo, Norway; ³Departement of Neuro-oncology, Oslo University Hospital, Rikshospitalet, Oslo, Norway

Dynamic contrast-enhanced MRI is an established method of assessing brain hemodynamics and blood-brain-barrier integrity in brain tumors. The kinetic properties of the tumor is estimated from the measured signal intensity change following the administration of a contrast agent. However, there is no consensus on the temporal parameters required to obtain accurate and reproducable estimates from such measurements. Temporal resolution and total sampling duration affects the quality of the resulting parameter maps and is of practical importance in the clinic. The present work investigates how these parameters are best chosen to achieve reliable results in high-grade brain tumors.