Fernando Calamante1, 2, Young-Don Son3, Jacques-Donald Tournier1, 2, Taek-Hyun Ryu3, Se-Hong Oh3, Alan Connelly1, 2, Zang-Hee Cho3
1Brain Research Institute, Florey Neuroscience Institutes, Heidelberg, Victoria, Australia; 2Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia; 3Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon, Korea, Republic of
We describe the first combination of PET images and whole-brain diffusion MRI fibre-tracking data, to generate super-resolution track-weighted PET maps (with 250m isotropic resolution). This method is based on the recently proposed technique of super-resolution track-weighted imaging (TWI), which combines the information from whole-brain fibre-tracking with a reference image, to generate a super-resolution track-weighted version of that image. The method is illustrated on 11C-DASB, a radioligand with high affinity for serotonin transporters. The proposed technique of TW-PET opens up new possibilities in molecular imaging, by combining the high sensitivity to brain biomarkers from PET and the super-resolution capabilities of TWI.