Simultaneous Estimation of Compartment Size and Eccentricity with Double-Wave-Vector Tensor Imaging at Long Mixing Times

Marco Lawrenz¹, Jrgen Finsterbusch¹

Double-wave-vector diffusion-weighting (DWV) experiments are a promising tool to investigate the tissue microstructure by considering the signal amplitude vs. the relative angle between the two wave vectors. While for short mixing times between the two diffusion-weighting periods involved, the signal modulation is proportional to the cell size, it increases with the cell eccentricity at long mixing times. Here, it is shown that with an appropriate direction combination scheme all elements of the recently presented tensor model for DWV experiments at long mixing times can be determined which allows the estimation of compartment sizes and cell eccentricities within a single experiment.