Keigo Shimoji1, Shigeki Aoki1, Osamu Abe2, Takanori Uka3, Yoshifumi Tamura4, Koji Kamagata1, Koichi Asahi1, Masaaki Hori1, Atsushi Nakanishi1, Yasmin Hasina1
1Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan; 2Department of Radiology, Nihon University Graduate School of Medicine, Tokyo, Japan; 3Department of Neurophysiology, Juntendo University Graduate School of Medicine, Tokyo, Japan; 4Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan
We explore the regional pattern of white matter alteration in metabolic subjects. In addition, we investigate whether white matter alteration was related to BMI. TBSS analysis revealed significantly lower FA values in metabolic subjects compared to normal control subjects in the part of the right external capsule, the entire corpus callosum and part of deep white matter of the right frontal lobe. By using tract-specific analysis, the mean FA value of right inferior fronto-occipital fasciculus was significantly lower in metabolic subjects compared with normal control subjects. A significantly statistical negative correlation was observed between BMI and FA values of right inferior fronto-occipital fasciculus.