Gisela E. Hagberg1, Ilgar Mamedov1, Anthony Powers1, Michael Beyerlein1, Hellmut Merkle2, Goran Angelovski1, Nikos K. Logothetis1
1MPI Biological cybernetics, Tubingen, Germany, Germany; 2LFMI-NINDS, National Institutes of Health, Bethesda, MD, United States
Measurements of the diffusion properties of substances in the cerebral extra-cellular space (ECS) can be used to study drug delivery/clearance and brain tissue structure. Currently used methods have high sensitivity, but are limited to single spatial points or are performed post mortem, or has a limited depth penetration. Here we explore the use of MRI during direct infusion of T1 relaxating agents and mathematical modelling for investigating ECS diffusion.