Yan Li1, Peder Larson1, Albert Chen2, Douglas Kelley, 13, Susan Chang4, Sarah J. Nelson1, 5
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States; 2GE Healthcare, Toronto, Ontario, Canada; 3GE Healthcare, San Francisco, CA, United States; 4Department of Neurosurgery, University of California, San Francisco, CA, United States; 5Department of Bioengineering and Therapeutic sciences, University of California, San Francisco, CA, United States
The purpose of this study was to compare metabolite ratios in the T2 lesion for 5 patients with glioma relative to ratios in 3 normal volunteers using H-1 MRSI. The use of 7 Tesla provided high SNR and spectral resolution. The presence of low Cho/Cr, NAA/Cr, Cho/Cr and mI/Cr were suggestive of edema, while high Cho/Cr and low NAA/Cr were interpreted as active tumor and low NAA/Cr and high mI/Cho as being suggestive of treatment effects. Our results suggest that using a combination of metabolite ratios would be helpful in the interpretation of treatment response.