Juyeun Park1, YoonSeok Choi2, Yunjung Lee3, Jisu Woo4, In-Chan Song4, Ji-Hoon Kim4, Hyeonjin Kim4
1Department of Biomedical Sciences , Seoul National University College of Medicine, Seoul, Korea, Republic of; 2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of; 3Lee Gil Ya Cancer and Diabetes Institute, Incheon, Korea, Republic of; 4Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of
Hepatic encephalopathy (HE) is a serious neuro-psychiatric complication of liver disease. To elucidate the pathogenesis of HE, 31P-MRS has been used. However, previous findings remain controversial due, at least in part, to relatively low sensitivity of the nucleus and limited spectral dispersion at low field. To this end, we have characterized HE in animal using 31P-MRS with substantially improved spectral dispersion and SNR at 9.4 T. Our results demonstrate that 31P-MRS at high field allows for highly resolved spectra in vivo, and thus can provide more vivid picture of the altered brain metabolism in the progression of HE.