Alexandra Constantin1, Adam Elkhaled2, Llewellyn Jalbert1, Kenneth Smith2, Tracy McKnight2, Annette Molinaro2, Joanna Phillips2, Susan M. Chang2, Sarah J. Nelson2
1University of California, Berkeley, Berkeley, CA, United States; 2University of California, San Francisco
The HRMAS metabolic profiles of recurrent and newly diagnosed grade 2 and 3 gliomas were compared in order to examine the changes that occur after treatment. Lower levels of myo-inositol/total choline (MCI) were found in recurrent gliomas. Higher levels of glutathione and MCI were detected in the recurrent grade 2 gliomas. Higher levels of taurine and aspartate and lower MCI levels were recorded in recurrent grade 3 gliomas compared to their newly diagnosed counterparts. Multivariate models were able to distinguishing between the recurrent and newly diagnosed tumors with more than 90% accuracy, suggesting that these lesions are metabolically distinct.